Let cost effectiveness models be open to scrutiny

Cost Effectiveness of Open Access Publications

Open access publishing has been proposed as one possible solution to the serials crisis—the rapidly growing subscription prices in scholarly journal publishing. However, open access publishing can present economic pitfalls as well, such as excessive article processing charges. We discuss the decision that an author faces when choosing to submit to an open access journal. We develop an interacti...

Should Pharmaceutical Product Hopping Be Subject to Antitrust Scrutiny?

On September 15, 2014, the New York State Attorney General filed a lawsuit against a brand pharmaceutical manufacturer alleging anticompetitive “product hopping.” The suit alleged that when defendant Actavis executed a “forced switch” of the market for its blockbuster Alzheimer’s drug, Namenda IR, to impel patients to purchase a new version, it engaged in product hopping and violated the Sherma...

Let There Be Light!

The invention of the microscope has been fundamental for the understanding of tissue architecture and subcellular structures. With the advancement of higher magnification microscopes came the development of various molecular biology tools such as Förster resonance energy transfer (FRET) and in situ proximity ligation assay (in situ PLA) to monitor protein interactions. Microscopy has become a c...

Let There Be Light

Let There Be Sight

levels. This fits well with the observation that the repul-1998). It remains to be seen, however, whether these or 1133.102, 363–375. tions be in mediating guidance decisions at choice points? Another possible site for this mechanism to operate is at the ventral midline of the CNS. In vertebrates, commissural axon crossing of the ventral midline of the spinal cord is regulated by a combination ...